Yes, absolutely. All of these things.
Really, it would speed up workflow for me because I could sculpt an entire map in Blender, render in the appropriate aspect ratio, and break the render into tiles in the editor. Merely because of the design of my game, it would actually be easiest.
In addition, it would be great for the tool to discern the difference between the transparent and non-transparent sections of a PNG file, so it could rule out and discard unnecessary tiles. If you look at the link in Bjorn’s post, that fellow who made it in 2012 had the tool down perfectly. It just wasn’t submitted…
Edit: Like you said, specific resolution and/or pixel sizing options would be a must.